GENEVA, Switzerland (CNN) -- The number of confirmed H1N1 cases soared to 615 on Saturday with the World Health Organization reporting 15 countries were infected with the virus commonly known as swine flu.
The organization had reported 367 cases on Friday. The jump in cases was due to ongoing testing of a backlog of of specimens in Mexico, the WHO said.
The most cases were in Mexico, where 397 people are infected, according to WHO. The United States is second with 141 cases.
"What the increase reflects is that we are moving forward in confirming many of the cases that have been left untested for some time, so in an way that's reassuring," said WHO spokesman Paul Garwood. "We know that these cases are being dealt with, these specimens are being looked at and assessed, and we're getting more and more info about this virus.
"So we haven't seen, say, a spike in new cases or new influenza cases appearing in Mexico City, for example," Garwood continued. "It's just the fact that this reporting backlog is bearing fruit and we're seeing the results of that."
Hundreds of guests and staff were under quarantine in China on Saturday after health officials determined that a hotel guest had contracted the H1N1 virus.
Nearly 200 hotel guests and 100 staff members were ordered to stay in Metropark Hotel in Hong Kong for seven days to stop the spread of the H1N1 virus, a government spokesman said.
The quarantine was ordered after a 25 -year-old Mexican man stayed in the hotel and became sick, according to the spokesman. The man reportedly flew from Mexico to Shanghai on April 30 and then went to Hong Kong.
The traveler was taken to a hospital and tests confirmed that he had the virus, said York Chow, the secretary for food and health.
Chow said officials would isolate the hotel and that "relevant people" would be quarantined for seven days and treated with an anti-viral medication, commonly known as Tamiflu.
It is the first confirmed case of the virus in Hong Kong, local medical officials said. None of the cases have been confirmed in mainland China.
South Korean officials on Saturday confirmed their first case -- a 51-year-old nun who recently traveled to Mexico for volunteer work.
The other countries with confirmed cases are Canada, with 34; Spain and the United Kingdom, which each have 13; Germany and New Zealand, which each have four; Israel, with two; and Austria, China, Denmark, France, the Netherlands, South Korea, and Switzerland, which each have one
As the number of swine flu cases across the globe is expected to rise, scientists are racing to develop a vaccine to confront the virus.
The Centers for Disease Control and Prevention in Atlanta, Georgia, hopes to have a vaccine for the virus available to manufacturers within a month, said Michael Shaw, the agency's lab team leader for the virus response.
"We're doing the best we can as fast as we can," he said.
Still, it would take four to six months from the time the appropriate strain is identified before the first doses become available, said Dr. Marie-Paule Kieny, WHO director of the Initiative for Vaccine Research.
"Of course, we would like to have a vaccine tomorrow. We would have wanted to have it yesterday," she said. "It's a long journey."
Kieny said there is "no doubt" that a vaccine can be made "in a relatively short period of time."
Producing a vaccine involves isolating a strain of the virus, which has already been done, and tweaking it so manufacturers can make a vaccine, Kieny said.
Once the virus reaches manufacturers, it faces additional testing before national regulatory agencies decide whether to approve a vaccine.
CDC officials were asked Friday how the H1N1 virus measures up to the deadly virus that sparked the 1918 Spanish flu pandemic.
"What we have found by looking very carefully at the sequences of the new H1N1 virus is that we do not see the markers for virulence that were seen in the 1918 virus," said Nancy Cox, chief of the CDC's Influenza Division.
However, she added, "we know there's a great deal that we do not yet understand about the virulence of the 1918 virus or other influenza viruses that have a more severe clinical picture in humans."
As researchers work, the mayor of Mexico City expressed optimism Friday.
Authorities in Mexico are "beginning to see evidence that the (virus) might be letting up, and the number of people who have been hospitalized has leveled out in regards to people who are contagious, at least as of yesterday," Mayor Marcelo Ebrard told reporters.
"I do not say this so that we lower our guard or so that we think that we do not have a problem anymore," he said.
"We do have a problem, but I say this so that we know where we are as a city after we have done all we have done, and in what direction we are heading and how much we have progressed. And what I can say is that we are heading in the right direction."
The CDC gave the following state-by-state breakdown of the 141 confirmed H1N1 cases in the United States: Arizona, 4; California, 13; Colorado 2; Delaware, 4; Illinois, 3; Indiana, 3; Kansas, 2; Kentucky, 1; Massachusetts, 2; Michigan, 2; Minnesota, 1; Nebraska, 1; Nevada, 1; New Jersey, 5; New York, 50; Ohio, 1; South Carolina, 16; Texas, 28; and Virginia, 2.
One death in the United States has been attributed to swine flu -- a toddler from Mexico whose family brought him to Texas for medical treatment.
At a Cabinet meeting Friday, President Barack Obama praised the "extraordinary" government response to the virus but emphasized that "we also need to prepare for the long term."
"Since we know that these kinds of threats can emerge at any moment, even if it turns out that the H1N1 is relatively mild on the front end, it could come back in a more virulent form during the actual flu season, and that's why we are investing in our public health infrastructure."
Several other countries were investigating hundreds of other probable cases of the virus
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